Enzyme assays can be split into two groups according to their sampling method : "'continuous assays "', where the assay gives a continuous reading of activity, and "'discontinuous assays "', where samples are taken, the reaction stopped and then the concentration of substrates / products determined.
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Because Tay Sachs disease was one of the first autosomal recessive genetic disorders for which there was an enzyme assay test ( prior to polymerase chain reaction testing methods ), it was intensely studied as a model for all such diseases, and researchers sought evidence of a selective process.
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