Very nonselective agonists of 5-HT receptor subtypes include ergotamine ( an antimigraine ), which activates 5-HT1A, 5-HT1D, 5-HT1B, D2 and norepinephrine receptors.
42.
Drugs derived from natural sources are usually produced by harvesting the natural source or through semisynthetic methods : one example is the semisynthesis of LSD from ergotamine, which is isolated from ergot fungus cultures.
43.
Adrenaline injections, mercury, various hormone treatments ( ovarian extracts, growth hormone, stilboestrol ), and ergotamine tartrate are among other treatments at some time used without significant or long-term benefit.
44.
And certainly it never occurred to him to look for heart valve problems because no drug, with the possible exception of high doses of ergotamines for migraines, had ever been known to damage heart valves.
45.
For one thing, it's much more difficult to obtain ergotamine tartrate, the precursor from which LSD is usually made, than it is to obtain the precursors of other illegal drugs such as methamphetamine.
46.
Ergotamine is the main psychoactive product of ergot fungi, it is structurally related to the recreational drug lysergic acid diethylamide ( LSD-25 ), and is the substance from which LSD-25 was originally synthesized.
47.
Ergot contains no lysergic acid diethylamide ( LSD ) but rather ergotamine, which is used to synthesize lysergic acid, an analog of and precursor for synthesis of LSD . Moreover, ergot sclerotia naturally contain some amounts of lysergic acid.
48.
Dr . Hartzell V . Schaff, the surgeon who replaced the woman's valve, remarked to Connolly that the valve was glistening and white, and looked like those that had been damaged when patients took ergotamine for long periods of time.
49.
The supply of constituent chemicals including lysergic acid, which was used for production of LSD in the 1960s, and ergotamine tartrate, which was used for production in the 1970s, were placed under tight surveillance and government funding for LSD research was almost completely eliminated.
50.
:* Hi, I wondered about that as well; but I eventually chose the more general name, "'cyclol "', which refers to a historical protein model, a chemical reaction and a class of chemical compounds such as ergotamine.
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