41. In the body, collagen fibrils are composed of several types of collagen as well as macromolecules. 42. In certain zonular intercellular junctions, rather than tight junctions, with clefts formed by extracellular fibrils . 43. Lum knockout mice also have abnormal collagen in their heart tissue, with fewer and thicker fibrils . 44. Eventually, the fragments form oligomers, then fibrils , beta-sheets, and finally plaques. 45. The homogenizers are used to delaminate the cell walls of the fibers and liberate the nanosized fibrils . 46. The spines are composed of a moderately electron-dense material with denser fibrils embedded within it. 47. Many tropocollagens then bind together to form a fibril , and many of these then form a fibre. 48. The products of the first three genes apparently are involved in the actual synthesis of the cellulose fibrils . 49. Unlike primary dentin, mantle dentin lacks phosphorylation, has loosely packed collagen fibrils and is less mineralized. 50. SR proteins are located in two different types of nuclear speckles, interchromatin granule clusters and perichromatin fibrils .