In addition, 7, 8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity.
42.
Feldman's hypothesis about the possible cause of the Middleborough cluster centers on genotoxicity, the theory that exposure to certain environmental toxins _ such as pesticides or heavy metals _ can damage the DNA, or genetic sequences, of susceptible individuals.
43.
Although some " in vitro " genotoxicity of verbascoside has been reported on human lymphocytes with an involvement of PARP-1 and p53 proteins, subsequent " in vivo " tests reported no genotoxicity for high dosage oral administration.
44.
Although some " in vitro " genotoxicity of verbascoside has been reported on human lymphocytes with an involvement of PARP-1 and p53 proteins, subsequent " in vivo " tests reported no genotoxicity for high dosage oral administration.
45.
Priority polycyclic aromatic hydrocarbons identified by the US EPA, the US Agency for Toxic Substances and Disease Registry ( ATSDR ), and the European Food Safety Authority ( EFSA ) due to their carcinogenicity or genotoxicity and / or ability to be monitored are the following:
46.
The second process includes the direct binding of chromium ( V ), produced by reduction in the cell, and chromium ( IV ) compounds to the DNA . The last mechanism attributed the genotoxicity to the binding to the DNA of the end product of the chromium ( III ) reduction.
47.
These intermediates and metabolites induce genotoxicity by multiple mechanisms including inhibition of topoisomerase II ( which maintains chromosome structure ), disruption of microtubules ( which maintains cellular structure and organization ), generation of oxygen free radicals ( unstable species ) that may lead to point mutations, increasing oxidative stress, inducing DNA strand breaks, and altering DNA methylation ( which can affect gene expression ).
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