41. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. 42. In 1933 the Ochoas returned to Madrid where he began to study glycolysis in heart muscle. 43. Glucagon turns off glycolysis in the liver, causing glycolytic intermediates to be shuttled to gluconeogenesis. 44. PFK-1 is an enzyme that controls one of the most critical steps of glycolysis . 45. There is a small amount of FBPase activity during glycolysis and some PFK1 activity during gluconeogenesis. 46. This bypasses the enzymatic defect in glycolysis , lessening the impact of the mutated PFKM enzymes. 47. Glycolysis is summarized by the equation:48. Similar to glycolysis , the pentose phosphate pathway appears to have a very ancient evolutionary origin. 49. But more recently it was suggested that inhibition of hexokinase activity leads to defects in glycolysis . 50. The results of FBA on a prepared metabolic network of the top six reactions of glycolysis .
