The features generally used to define a MDS are : blood cytopenias; ineffective hematopoiesis; dyserythropoiesis; dysgranulopoiesis; dysmegakaropoiesis and increased myeloblasts.
42.
In a human embryo : " the 28-day stage . . . marks the onset of human intra-embryonic hematopoiesis ".
43.
MafB is a basic leucine zipper ( bZIP ) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis.
44.
Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development.
45.
Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis.
46.
Hematopoiesis is defined as the formation and development of blood cells, all of which are derived from hematopoietic stem-progenitor cells ( HSPCs ).
47.
Thrombopoietin regulates the differentiation of megakaryocytes and platelets, but studies on the removal of the thrombopoietin receptor show that its effects on hematopoiesis are more versatile.
48.
Interleukin 1 alpha and interleukin 1 beta ( IL1 beta ) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis.
49.
This seminal study demonstrated that engrafted bone marrow stem cells contribute to long-term hematopoiesis and also that contaminating tumor cells in autografts can cause relapse.
50.
Regarding extramedullary hematopoiesis, it's my understanding that minimal ( i . e . negligible ) hematopoiesis occurs in lymphoid tissue even in healthy adults.
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