41. Kallmann syndrome ( KS ) and other forms of hypogonadotropic hypogonadism ( HH ) are classed as pituitary or endocrine disorders. 42. A high level of prolactin in the blood can inhibit the release of gonadotropin releasing hormone and therefore cause central hypogonadism . 43. However, it is well established that men with a condition known as hypogonadism do benefit from testosterone replacement, Tenover said. 44. An estimated 4 million to 5 million Americans have hypogonadism , but only about 5 percent are thought to be getting treatment. 45. Other terms used include idiopathic / isolated hypogonadotropic hypogonadism ( IHH ), normosmic hypogonadotropic hypogonadism ( nHH ) or hypothalamic hypogonadism. 46. Other terms used include idiopathic / isolated hypogonadotropic hypogonadism ( IHH ), normosmic hypogonadotropic hypogonadism ( nHH ) or hypothalamic hypogonadism. 47. Other terms used include idiopathic / isolated hypogonadotropic hypogonadism ( IHH ), normosmic hypogonadotropic hypogonadism ( nHH ) or hypothalamic hypogonadism . 48. In 1922, he described his studies of two sisters who had retinitis pigmentosa, polydactyly, hypogonadism as well as obesity. 49. As males age, the testes begin to produce less testosterone, leading to a condition known as post-pubertal hypogonadism . 50. Individuals with Kallmann syndrome experience anosmia ( lack of smell ) and do not go through puberty ( hypothalamic hypogonadotropic hypogonadism ).