41. The DMH is also involved in the regulation of hypothalamic outflow to the autonomic nervous and endocrine systems. 42. These results were obtained from postmortem analysis of hypothalamic nuclei of known homosexual subjects compared to heterosexual patients. 43. In the hypothalamic -pituitary-adrenal axis the pituitary release of ACTH is regulated by the hypothalamus. 44. In the cortisol awakening response, the hypothalamic -pituitary-adrenal axis is controlled by the hippocampus. 45. Cytokine regulation of hypothalamic function is an active area of research for the treatment of anxiety-related disorders. 46. A delay in the reactivation of the hypothalamic -pituitary pulse generator results in a later onset of puberty. 47. The researchers gave injections of Amgen's synthetic leptin to eight competitive women athletes, all with hypothalamic amenorrhea. 48. The most significant difference may be the presence of an abnormality in the hypothalamic pituitary adrenal axis ( HPA ). 49. It seems that the most essential of all these connections is the SFO s projections to the paraventricular hypothalamic nucleus. 50. CB 1 receptors are highly expressed in hypothalamic areas which are involved in central food intake control and feeding behavior.