41. Its catalytic site involves sulfohydryl group of Cys-285 and the imidazole ring of its His-237. 42. "' Imidazole "'is an organic compound with the formula C 3 N 2 H 4. 43. The name " imidazole " was coined in 1887 by the German chemist Arthur Rudolf Hantzsch ( 1857 1935 ). 44. Several rings contain basic as well as non-basic nitrogen atoms, e . g . imidazole and purine. 45. In such model complexes, the Tp " simulates the coordination environment provided by three imidazole ligands in proteins. 46. 2-Methylimidazole is a sterically hindered imidazole that is used to similuate the coordination of histidine to heme complexes. 47. This is potentially due to a lead lone pair of electrons, also found in lead complexes with an imidazole ligand. 48. Imidazole is used to elute tagged proteins bound to nickel ions attached to the surface of beads in the chromatography column.49. Modification of histidine by DEPC results in carbethoxylated derivates at the N-omega-2 nitrogen of the imidazole ring. 50. Ketoconazole is an imidazole derivative is used as a broad-spectrum antifungal agent effective against a variety of fungal infections.
