"' Eukaryotic initiation factor 3 ( eIF3 ) "'is a multiprotein complex that functions during the initiation phase of eukaryotic translation.
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Stress granules contain non-translating mRNAs and translation initiation factors, suggesting that they may form as a result of aggregation of mRNPs stalled during translation initiation.
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Phosphorylation of eukaryotic initiation factor 4e ( eif-4E ) [ 4EBP ] by mTOR inhibits the capacity of 4EBP to inhibit eif-4E and slow metabolism.
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It is located in the 5'untranslated regions of mRNAs encoding initiation factor 3 followed by ribosomal proteins L35 and L20 ( infC-rpmI-rplT ).
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Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.
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Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4A-II, two other members of the DEAD box protein family.
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CroV can then translate the mRNA into DNA, again without the help of the cell, by using its own tRNA synthetase, tRNA, and translation initiation factors.
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Rli1p has been found to co-purify with eukaryotic initiation factors, specifically eIF2, eIF5, and eIF3, as well as the 40S subunit of the ribosome.
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Poliovirus is also involved in the cleavage of eIF4E ( Eukaryotic translation initiation factor 4E ) . eIF4E is a protein involved in directing Eurkaryotic ribosomes in cap dependent translation.
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FMRP directly binds CYFIP1, which in turn binds the translation initiation factor eIF4E . The FMRP-CYFIP1 complex prohibits eIF4E-dependent initiation, thereby acting to repress translation.
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