This includes the regulation of intestinal epithelium growth ( enhanced healing of gastrointestinal lesions ), the inhibition of adipogenesis, the induction of acute phase protein synthesis ( e . g ., fibrinogen ), and inhibition of macrophageal released pro-inflammatory cytokines.
42.
P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics ( such as toxins or drugs ) back into the intestinal endothelial cells composing the blood brain barrier and blood-testis barrier, where it pumps them back into the capillaries.
43.
A well studied model is celiac disease, in which increased intestinal permeability appears secondary to the abnormal immune reaction induced by gluten and allows fragments of gliadin protein to get past the intestinal epithelium, triggering an immune response at the intestinal submucosa level that leads to diverse gastrointestinal or extra-gastrointestinal symptoms.
44.
During human development, " ERBB3 " is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium . " ERBB3 " is expressed in normal adult human gastrointestinal tract, reproductive system, skin, nervous system, urinary tract, and endocrine system.
45.
In humans the gut flora is established at one to two years after birth, and by that time the intestinal epithelium and the intestinal mucosal barrier that it secretes have co-developed in a way that is tolerant to, and even supportive of, the gut flora and that also provides a barrier to pathogenic organisms.
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