41. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. 42. An immobile xylose isomerase that was fixed on a solid surface was first developed in Japan by Takanashi. 43. Glucose isomerase also has a much higher affinity for xylose than for glucose, necessitating a carefully controlled environment. 44. Dermorphin appears to be made in these through an unusual posttranslational modification carried out by an amino acid isomerase . 45. The isomerase activity of RPE65 has been shown; it is still uncertain whether it also acts as hydrolase. 46. The SLBP RBD also undergoes proline isomerization about this sequence and is a substrate for the prolyl isomerase Pin1. 47. They further tested carcinogens such as polycyclic aromatic hydrocarbons as well as the structure of the enzyme xylose isomerase . 48. With a single diagnosed patient only, ribose-5-phosphate isomerase deficiency is considered the rarest genetic disease. 49. The addition of a potential prolyl isomerase will accelerate this latter reaction phase if it has true prolyl isomerase activity. 50. The addition of a potential prolyl isomerase will accelerate this latter reaction phase if it has true prolyl isomerase activity.