In a mouse model of autoantibody mediated anemia using IgG isotype switch variants of an anti erythrocytes autoantibody, it was found that mouse IgG2a was superior to IgG1 in activating complement.
42.
Neurath invited the young artists to come to Vienna in 1928, and work on further developing his ISOTYPE . Arntz designed around 4000 different pictograms and abstracted illustrations for this system.
43.
In 1941, after release from internment ( as " enemy aliens " ), Marie and Otto Neurath were married, and resumed their work in Oxford, founding the Isotype Institute.
44.
Visual education was always the prime motive behind Isotype, which was worked out in exhibitions and books designed to inform ordinary citizens ( including schoolchildren ) about their place in the world.
45.
More importantly, FO B cells require CD40-CD40L dependent T FH cell help to promote effective primary immune responses and antibody isotype switching and to establish high-affinity B cell memory.
46.
Rudolf Modley, who served as an assistant to Otto Neurath in Vienna, introduced ISOTYPE methods to the United States through his position as chief curator at the Museum of Science and Industry in Chicago.
47.
Furthermore, by 1934 Modley established Pictorial Statistics Incorporated in New York, a company which promoted the production and distribution of ISOTYPE-like pictographs for education, news, and other forms of communications.
48.
A defining project of the first phase of Isotype ( then still known as the Vienna Method ) was the monumental collection of 100 statistical charts, " Gesellschaft und Wirtschaft " ( 1930 ).
49.
The way the B cell " select " which isotype to express and which isotypes to excise during DNA recombination is dependent upon which cytokine signals are present near the B cell at the time of recombination.
50.
These variations in primary structure affect the paclitaxel ( a mimic of Nur77 ) binding domain on ?III-tubulin and may account for the ability of this isotype to confer resistance to Nur77-initiated apoptosis.
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