41. APCCdc20 is a ubiquitin-protein ligase that tags the protein, securin, for destruction. 42. KAP1 forms a complex with MDM2 ( a ubiquitin E3 ligase ) that binds to p53. 43. This gene encodes a ubiquitin ligase that is specific for receptor-regulated BMP ) pathway. 44. CUL4B-based E3 ubiquitin ligase complexes often demonstrate overlapping activity with CUL4A-based complexes. 45. Multisynthetase complex auxiliary component p38 has been shown to interact with Parkin ( ligase ), P53 46. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. 47. The gene structure is completed by a cellular ligase present in both eukaryotic and prokaryotic cells. 48. The net result is that this ubiquitin ligase complex is important for limb outgrowth in embryos. 49. DNA ligase III-alpha participates in a minor alternative NHEJ pathway that generates chromosomal translocations. 50. Purified DNA ligase is used in gene cloning to join DNA molecules together to form recombinant DNA.
