41. He knew that living cells had a membrane potential ; interior negative to the environment. 42. Movement of calcium ions from the extracellular compartment to the intracellular compartment alters membrane potential . 43. In some type of neurons, the membrane potential can synchronous activity of neighboring neurons. 44. Depolarization is followed by the plateau phase, in which membrane potential declines relatively slowly. 45. TisB insertion into the membrane is thought to result in a loss of membrane potential . 46. It causes hyperkalemia, which stops the heart by inducing depolarization of cellular membrane potentials . 47. Action potentials are triggered when enough depolarization accumulates to bring the membrane potential up to threshold. 48. Thus, the membrane potential affects the permeability, which then further affects the membrane potential. 49. Thus, the membrane potential affects the permeability, which then further affects the membrane potential . 50. This causes the membrane potential to rise at a rate of about 300 V / s.