41. Currently, about 100, 000 women with breast cancer are living with bone metastases . 42. As long as mice had the large tumor, they had no signs of metastases . 43. If surgeons remove the primary tumor, in some cases the metastases grow more aggressively. 44. The surgery for resection of brain metastases went smoothly with no post-operative complications, 45. In December 2014 metastases from the ocular tumour were discovered in his liver and brain. 46. Heterogeneity is commonly retained by tumor metastases . 47. FOXC2 is also involved in cancer metastases . 48. It has been proposed as a possible chemotherapeutic agent in the treatment of brain metastases . 49. It would be considered metastatic lung cancer or lung cancer with metastases to the bones. 50. Distant metastases are treated with hormonal therapy, chemotherapy, or a combination of both.