41. LC3 was originally identified as a microtubule associated protein in rat brain. 42. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. 43. During mitosis, the protein associates with spindle microtubules near the centrosomes. 44. During metaphase, the kinetochore microtubules connect to the centromere. 45. Free microtubules elongate the initial cylindrical structure of procentrioles to form centrioles. 46. The MIP-T3 microtubule binding domain stretches from 909-1176. 47. The PCM is essential for nucleation and organization of microtubules . 48. Second, the centrosomes are separated via microtubules motor proteins. 49. Microtubule is involved in different stages of the cell cycle.50. In contrast to colchine, vinca alkaloids bind to the microtubule directly.
