41. Certolizumab pegol is a monoclonal antibody directed against tumor necrosis factor alpha. 42. The few documented bites involved pain and minor swelling with minimal necrosis . 43. Analgesic nephropathy is a common cause of renal papillary necrosis . 44. ESWT is also used to promote bone healing and treat bone necrosis . 45. The virus also causes spraing and necrosis in the flesh of tubers. 46. This lethality phenotype could be rescued by inhibition of tumor necrosis factor. 47. This gene belongs to the tumor necrosis factor receptor superfamily. 48. The combination of the conditions was given the name acute retinal necrosis . 49. Necrosis can ( in turn ) cause intraocular and rarely orbital inflammation.50. This wound may be susceptible to local ulcerations and necrosis .