41. In some chordates, it persists throughout life as the main ventral to the neural tube . 42. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. 43. Closure of the neural tube occurs in the middle, and then moves superiorly and inferiorly. 44. Concluding that folic acid supplementation might be an effective method of neural tube defect prevention. 45. Expression of these proteins is essential to neural plate folding and subsequent neural tube formation. 46. The negligence lawsuit was originally brought by 27 families of children suffering from neural tube defects. 47. The dorsal neural tube is patterned by BMPs from the epidermal ectoderm flanking the neural plate. 48. Scientists say genes could be a major factor in determining where neural tube defects will strike. 49. Folic acid intake during pregnancy has been linked to a lessened risk of neural tube defects. 50. The two groups of researchers were studying infants born with neural tube defects ( NTDs ).