Oncogenic fusion genes may lead to a gene product with a new or different function from the two fusion partners.
42.
Oncogenic factors, including mistranscription, are hypothesized to be related to the degree of phenotypic variation among affected individuals.
43.
TFAP2C has also been shown to have an oncogenic role by promotion of cell proliferation and tumour growth in neuroblastoma.
44.
The application of such systems to low frequency processes such as oncogenic transformation depends very much on the technology involved.
45.
This work provided key insights into how both virus and cellular oncoproteins manipulate cellular physiology to bring about oncogenic transformation.
46.
The staining of these inhibitors has not commonly been looked at regardless of their affect on oncogenic functions within the cell.
47.
In recent gene therapy trials, the lentiviral vectors used showed no tendency to disrupt gene function or promote oncogenic development.
48.
Lemmon s recent work has focused on the need to understand the biochemistry of oncogenic activation to use such drugs effectively.
49.
Another study showed that oncogenic transformation by ras and fos also requires Jun N-terminal phosphorylation at Serine 63 and 73.
50.
In addition, ROCK kinases influence more distal cellular processes including gene transcription, proliferation, differentiation, apoptosis and oncogenic transformation.
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