41. "' Cogazocine "'( INN ) is an opioid analgesic of the benzomorphan family which was never marketed. 42. "' Butinazocine "'( INN ) is an opioid analgesic of the benzomorphan family which was never marketed. 43. "' Levomethorphan "'( BAN ) is an opioid analgesic of the morphinan family that has never been marketed. 44. Toll-like receptor 4 has been shown to be important for the long-term side-effects of opioid analgesic drugs. 45. Phenadoxone is generally considered to be a strong opioid analgesic and is regulated in much the same way as morphine where it is used. 46. "' Lofentanil "'is one of the most potent opioid analgesics known and is an affinity from increasing much further. 47. "' SNC-80 "'is an opioid analgesic drug that selectively activates heteromers and is used in scientific research. 48. "' U-77891 "'is an opioid analgesic drug that was first synthesized in 1983 by the Upjohn company. 49. "' Diampromide "'is an opioid analgesic from the ampromide family of drugs, related to other drugs such as propiram. 50. "' Furethidine "'is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine ( meperidine ).