41. GDF2 induces the differentiation of mesenchymal stem cells ( MSCs ) to an osteoblast lineage. 42. It induces human osteoblast differentiation through extracellular signal-regulated kinase 1 / 2 pathway. 43. But in osteoporosis, the osteoblasts can't keep pace with the bone-destroyers. 44. The osteoblast cell forms new bone, while osteoclast dissolves old and worn out bone tissue. 45. Osteoblasts are responsible for bone formation.46. Unlike the much larger osteoclasts, osteoblasts are much smaller; they only have one nucleus. 47. Osteoblasts are important because they allow the bones to be made, remodeled, and repaired.48. Osteoblasts create bone and osteoclasts destroy it, especially if force is placed on a tooth.49. Bone is resorbed by osteoclasts, and is deposited by osteoblasts in a process called ossification. 50. Rodan researched the connection between osteoblasts and osteoclasts and helped to analyse and describe the two.
