41. Cinobufagin can induce cell cycle arrest at the G2 and M phases as well as induce apoptosis in osteosarcoma cells. 42. Kurt is a cancer survivor who lost his left leg, above the knee, to an osteosarcoma in 1988. 43. It turns out that osteosarcoma , fast-moving and very painful bone cancer, had been causing her recent limp. 44. He was given less than a 50-50 chance of surviving for three years after he was diagnosed with osteosarcoma . 45. Most times, the early signs of osteosarcoma are caught on X-rays taken during routine dental check-ups. 46. Long-term survival probabilities for osteosarcoma have improved dramatically during the late 20th century and approximated 68 % in 2009. 47. At the age of twelve, Delaney was diagnosed with osteosarcoma , the same cancer that Canadian hero Terry Fox had. 48. In 1973, when Kennedy was twelve, osteosarcoma ( a form of bone cancer ) was diagnosed in his right leg. 49. At Christmastime, Lacey's friends rallied'round again, when the news came that she had developed a new osteosarcoma . 50. His right leg was amputated in 1977 after he was diagnosed with osteosarcoma , though he continued to run using an artificial leg.