In 1992, for example, researchers discovered a gene mutation responsible for a peculiar muscle ailment in pedigreed quarter horses _ hyperkalemic periodic paralysis or HYPP . Horses that had the genetic defect were strikingly beautiful, and many became champions.
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Although Impressive was not known to have exhibited any symptoms of the disease himself, gradually it became evident that many horses tracing to Impressive were afflicted with the painful, alarming, and often fatal disease hyperkalemic periodic paralysis ( HYPP ).
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Genetic diagnosis is often unreliable as only a few of the more common gene locations are tested, but even with more extensive testing 20 37 % of people with a clinical diagnosis of hypokalemic periodic paralysis have no known mutation in the two known genes.
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Due to the heavy influx of American Quarter Horse breeding, some Paints may also carry genetic disorders such as Hyperkalemic Periodic Paralysis ( HYPP ), Hereditary Equine Regional Dermal Asthenia ( HERDA ), Equine polysaccharide storage myopathy ( called PSSM-polysaccharide storage myopathy-in Paints, Quarter Horses and Appaloosas ), Malignant hyperthermia ( MH ) and Glycogen Branching Enzyme Deficiency ( GBED ).
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