41. The scientists measured changes in TPA and another chemical, plasminogen activator inhibitor, PAI-1, which binds to TPA and neutralizes it. 42. The wonder treatment TPA, or tissue plasminogen activator , is still the best available for strokes _ but it's not risk-free. 43. Later, he collaborated in Leuven with D�sir?Collen to discover the clinical application of tissue plasminogen activator ( tPA ). 44. Altepase and similar drugs such as TPA ( tissue plasminogen activator ) are already a mainstay of heart attack treatment. 45. Furthermore, mRNA coding for tissue-type plasminogen activator is not translated until after most cortical granules have formed within the oocyte. 46. To be effective, however, tPA, or tissue plasminogen activator , must be given intravenously within three hours after onset of the stroke. 47. TPA, or tissue plasminogen activator , is manufactured by South San Francisco-based Genentech Inc . and sold under the trade name Activase. 48. Protein p11 can also be presented on the cell surface as a receptor for tissue-type plasminogen activator ( tPA ) and plasminogen. 49. TPA _ tissue plasminogen activator _ can dissolve clots that block arteries and has long been the mainstay of heart attack treatment. 50. In contrast, plasmin further stimulates plasmin generation by producing more active forms of both tissue plasminogen activator ( tPA ) and urokinase.
