Although NS3 domain's active role is not known yet, scientist propose that NS3 may interact with the active site of NS2 which would provided with catalytic environment necessary for polyprotein processing.
42.
The Mouse Mammary Tumor Virus ( MMTV ) " env " gene codes for a polyprotein that is cleaved to yield the surface ( SU ) and transmembrane ( TM ) Env products.
43.
Finally, many viruses express their genome as a single, massive polyprotein and use a protease to cleave this into functional units ( e . g . polio, norovirus, and TEV proteases ).
44.
The C-terminal part of the polyprotein contains sequence motifs typical of well-characterized picornavirus nonstructural proteins : an RNA helicase, a chymotrypsin-like 3C protease and an RNA-dependent RNA polymerase.
45.
The article has proposed the structure for NS2-3 cysteine protease active site and provided with in-vitro co-expression mutation study results which would change the way researchers currently look at polyprotein processing.
46.
Picornavirus genomes contain only a single open reading frame ( ORF ) which is translated into a single polyprotein, but CrPV, as well as several other related insect viruses, is translated from two ORFs.
47.
The capsid protein derived from the polyprotein Gag is assembled into a viral core ( the protein shell of a virus ) and the matrix protein also derived from Gag forms a shell immediately inside of the lipid bilayer.
48.
The ( + ) ssRNA ( positive, single-stranded RNA ) at first only acts as a template for the translation of the non-structural proteins, which are synthesized as a large polyprotein and are then cut into single proteins.
49.
A unique feature of this genus is the presence of the L * protein that is made out of frame from the polyprotein and is present in the DA subgroup of TMEV . It has been found to be important for the virus pathogenesis.
50.
The structural polyprotein is cleaved into 6 chains : Capsid protein ( C ), p62, E3 protein or spike glycoprotein E3, E2 envelope glycoprotein or spike glycoprotein E2, 6K protein, E1 envelope glycoprotein known also as spike glycoprotein E1.
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