In gene therapy, protamine sulfate has been studied as a means to increase transduction rates by both viral and nonviral ( e . g . utilizing cationic lipids ) mediated delivery mechanisms.
42.
The most widespread deoxyribonucleoproteins are nucleosomes, in which the component is nuclear DNA . The proteins are combined with DNA are histone ] s and protamines; resulting nucleoproteins are located in chromosomes.
43.
The rapid availability of results helps to discriminate surgical bleeding from a true haemostasis disorder and improves the therapy with blood products, factor concentrates, anticoagulants and protamine, hemostyptic and antifibrinolytic drugs.
44.
Polyelectrolytes such as dextran sulfate ( DSS ), protamine ( PRM ) or poly-L-arginine all fulfill these requirements and may be used as a capsule with an emulsion inside.
45.
A portion of the somatic histones are replaced by testis-specific histones, such as testis-specific histone 2B or TH2b, which are then replaced by transitional proteins and later protamines.
46.
However, emulsification of long-chain fatty acids for digestion and absorption in the small intestine is less constant in humans than rats, which will vary the effectiveness of protamine as a drug.
47.
In 1936, Hagedorn and B . Norman Jensen discovered that the effects of injected insulin could be prolonged by the addition of protamine obtained from the " milt " or semen of river trout.
48.
"It's put us in a panic . . . . If we're unable to get protamine, we'll have to think about canceling surgeries that aren't emergencies, " she said.
49.
Injections of insulin may either be added to oral medication or used alone . and do not appear much better than neutral protamine Hagedorn ( NPH ) insulin, but as they are significantly more expensive, they are not cost effective as of 2010.
50.
The ratio of protamine 2 to protamine 1 and transition nuclear proteins has been found to change the sperm head shape in various species of Mus, the genus of mice, by altering the expression of protamine 2 via mutations in its promoter region.
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