Reovirus replicates in and eventually kills Ras-activated tumour cells, and as cell death occurs, progeny virus particles are then free to infect surrounding cancer cells.
42.
He has been described as " one of the earliest molecular virologists " and is best known for his research on poxviruses and reoviruses, and for work on interferon proteins
43.
The sera of birds infected with avian reovirus display circulating antibodies through the validation of ELISA, agar gel immunodiffusion, indirect immunofluorescence ( IIF ), and virus neutralization ( VN ).
44.
Since its inception, Oncolytics Biotech Inc . has worked to take Reolysin, its proprietary formulation of human reovirus, through the development and regulatory requirements necessary to develop it as a potential cancer therapeutic.
45.
Gromeier also noted that although the reovirus does not produce any recognized disease in humans, there are many unknowns about the effect the virus might have if it were injected into the brain of a human.
46.
In addition, the encoded protein can act as ( 1 ) a receptor for reovirus, ( 2 ) a ligand for the integrin LFA1, involved in leukocyte transmigration, and ( 3 ) a platelet receptor.
47.
The ability of avian reovirus to induce apoptosis is not restricted to a distinct cell type of virus strain due to the fact that several different isolates of this pathogen could induce apoptosis in different mammalian and avian cell lines.
48.
Most of the plant infecting reoviruses are transmitted between plants by insect vectors . The viruses replicate in both the plant and the insect, generally causing disease in the plant, but little or no harm to the infected insect.
49.
"There are a number of aspects of the proposed strategies with reoviruses that are in the dark, " said Gromeier, a scientist who is researching the use of another type of virus in the treatment of cancer.
50.
Some Orphan Viruses include Adeno-Associated Virus ( Parvoviridae ), Human herpesvirus 7 ( Herpesviridae ), Human foamy virus ( Retroviridae ), Human Reovirus ( Reoviridae ), Hepatitis G ( Flaviviridae ), and TT Virus ( Circoviridae ).
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