41. Some cases of retinoblastoma are hereditary; others occur spontaneously, with no family history of the disease. 42. As with many cancers, gene therapy holds promise for the future treatment of retinoblastoma , Abramson said. 43. In normal cells, the retinoblastoma , or Rb, protein helps block an invading virus from reproducing. 44. In 1998, his infant daughter Katya was diagnosed with a rare cancer of the eye called retinoblastoma . 45. She is also co-editor of a comprehensive book entitled, " Retinoblastoma ", published recently. 46. Two forms of retinoblastoma were noticed : a bilateral, familial form and a unilateral, sporadic form. 47. Knudson theorized that two mutations that arose differently were needed to produce the hereditary and sporadic forms of retinoblastoma . 48. Although the disease may sometimes be hereditary, the majority of retinoblastoma patients have no history of the disease. 49. A recent meta-analysis has shown that survival of trilateral retinoblastoma has increased substantially over the last decades. 50. Although blinded by retinoblastoma at the age of three, she has succeeded in competitive swimming despite her disability.