Building on the work of Paul Ehrlich in Germany, who had developed an arsenic-derived drug called Salvarsan for the treatment for syphilis, chemist Walter A . Jacobs and immunologist Michael Heidelberger synthesized 243 possible arsenicals, varying methyl groups, amides, and complex side chains.
42.
He later cooperated with August Paul von Wassermann ( 1866 1925 ) to develop the famous diagnostic test for detecting " Treponema pallidum " infections, and also in the testing of the first chemotherapeutic agent for syphilis, Salvarsan, which was discovered by his former school fellow Paul Ehrlich in 1910.
43.
Ehrlich and Bertheim's 606th arsenobenzene, synthesized in 1907, was arsphenamine, found ineffective against microorganism involved in syphilis, a disease roughly equivalent then to today's AIDS . In the late 1940s, Salvarsan was replaced in most regions by penicillin, yet organic arsenicals remained in use for trypanosomiasis.
44.
However, Hal B . Wallis, president of the association, while advising caution, wrote to Warner Bros . that " to make a dramatic picture of the life of Dr . Ehrlich and not include this discovery [ the anti-syphilis drug Salvarsan ] among his great achievements would be unfair to the record ."
45.
Dieterle then made two more bio-pics, this time both starring Edward G . Robinson instead of Paul Muni . " Dr . Ehrlich's Magic Bullet " ( 1940 ) is about Paul Ehrlich's discovery of Salvarsan, which made syphilis curable; and " A Dispatch from Reuter's " ( also 1940 ), about the man who established the first news agency.
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