Interestingly, it is suggested this approach allows a smaller dose of the drug to be delivered directly to the site of action, with fewer systemic side effects, which is thus therapeutically questionable due to the fact that the three main opioid receptors; chiefly the [ ?-, ?-, and ? ( Mu-, Kappa-, and Delta-respectively ] are limited in their anatomical locations.
42.
While the use of paracetamol, aspirin, ibuprofen, naproxen, and other NSAIDS concurrently with weak to mid-range opiates ( up to about the hydrocodone level ) has been said to show beneficial synergistic effects by combatting pain at multiple sites of action, several combination analgesic products have been shown to have few efficacy benefits when compared to similar doses of their individual components.
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