This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.
42.
So the scientists conducted tests to see if blocking the sphingomyelin pathway by using the compound sphingosine-1-phosphate would protect the eggs in live animals.
43.
Because of their similarity, fumonisins are able to inhibit sphingosine-sphinganin-transferases and ceramide synthases and are therefore competitive inhibitors of sphingolipid biosynthesis and metabolism.
44.
Recent work on a sphingosine analogue, FTY270, demonstrates its ability to act as a potent compound that alters the activity of S1P receptors ( agonist ).
45.
Sphingosine 1-phosphate mediates many cellular processes including proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis.
46.
CerS2 activity is regulated by sphingosine-1-phosphate ( S1P ) via two sphingosine-1-phosphate receptor-like residues on CerS2 that operate independently.
47.
CerS2 activity is regulated by sphingosine-1-phosphate ( S1P ) via two sphingosine-1-phosphate receptor-like residues on CerS2 that operate independently.
48.
It acts as a sphingosine-1-phosphate ( S1P ) receptor agonist, sequestering lymphocytes to peripheral lymphoid organs and away from their sites of chronic inflammation.
49.
"' A-971432 "'is an orally bioavailable selective agonist of sphingosine-1-phosphate receptor 5 ( S1PR5 ) discovered at AbbVie.
50.
The necrosome also causes leakage of lysosomal digestive enzymes into the cytoplasm by induction of reactive oxygen species by JNK, sphingosine production, and calpain activation by calcium release.
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