41. The substantia nigra has a high quantity of dopaminergic neurons, which are nerve release the neurotransmitter known as dopamine. 42. In this model, the dopaminergic projections from the substantia nigra to the basal ganglia function as the prediction error. 43. The cause of Parkinson's is unknown, but it involves degeneration of a small brain area called the substantia nigra . 44. The anatomical link of the striatum with its primary targets, the pallidum and the substantia nigra , was discovered later. 45. The locomotor enhancing properties of cocaine may be attributable to its enhancement of dopaminergic transmission from the substantia nigra . 46. Purkyn was also the first to describe and illustrate in 1838 the intracytoplasmic pigment neuromelanin in the substantia nigra . 47. In vivo the direct administration of neurturin into substantia nigra of mice models also shows mature DA neuron protection. 48. Other changes in the substantia nigra include increased expression of NMDA receptors in the substantia nigra , and reduced dysbindin expression. 49. Researchers are looking for a gene that would protect the cells in the substantia nigra from being destroyed by Parkinson's. 50. Other changes in the substantia nigra include increased expression of NMDA receptors in the substantia nigra, and reduced dysbindin expression.
