41. This tumor suppressor gene is a member of a nuclear histone / protein methyltransferase superfamily. 42. Surprisingly, none of the 16 tumor-suppressor genes found so far have such a phosphate-removing role. 43. The tumor-suppressor genes are one group of housekeeping genes. 44. DCC can be considered a conditional tumour suppressor gene as well as a conditional oncogene. 45. Mutations in either the TSC1 or TSC2 tumor suppressor gene are responsible for TSC disease. 46. Dominant-negative mutations also occur in other tumor suppressor genes . 47. Many of the pathway components recognized as tumor suppressor genes are mutated in human cancers. 48. The first direct evidence for DCC as a tumour suppressor gene was published in 1995. 49. Next Baylin and his colleagues looked at p16, a tumor-suppressor gene linked to many cancers. 50. "APC " is classified as a tumor suppressor gene .
