Whereas MRI contrast depends on release of Mn 2 +, the MnSOD mimetic activity depends on Mn 2 + that remains bound to DPDP . "'Calmangafodipir "'[ Ca 4 Mn ( DPDP ) 5 ] ( brand name "'PledOx ) "'is stabilized with respect to Mn 2 + and has improved therapeutic activity.
42.
The ability of immunoglobulin therapy to suppress pathogenic immune responses by this mechanism is dependent on the presence of a sialylated glycan at position CH2-84.4 of IgG . Specifically, de-sialylated preparations of immunoglobulin lose their therapeutic activity and the anti-inflammatory effects of IVIG can be recapitulated by administration of recombinant sialylated IgG1 Fc.
43.
*"'US Patent ( 8, 747, 891 ) "'- Awarded to The Penn State Research Foundation and Keystone Nano's Chief Medical Officer Mark Kester, this patent describes the process of loading Ceramide nano-scale liposomes with anti-cancer compounds and create a combination of therapies that benefit from the therapeutic activity of both Ceramide and the anti-cancer compound.
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