Her other significant contributions include development of the stented aortic homograft ( a graft of same-species tissue, in this case human tissue ) for mitral valve replacement, surgical treatment of chronic thromboembolic disease, and pioneering techniques for the use of tissue cultures to discourage the formation of clots when prosthetic valves and circulatory assist devices are in use.
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The decision to anticoagulate people with HF, typically with left ventricular ejection fractions < 35 % is debated, but generally, people with coexisting atrial fibrillation, a prior embolic event, or conditions which increase the risk of an embolic event such as amyloidosis, left ventricular noncompaction, familial dilated cardiomyopathy, or a thromboembolic event in a first-degree relative.
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