Further, when CU-2010 and CU-2020 are continuously infused, the greater inhibition of factors Xa and XIa compared to that by aprotinin prevent early thrombosis, providing an anti-coagulatory effect in patients, and prolonging activated partial thromboplastin time ( aPTT ).
42.
This is opposed to the intrinsic ( amplification ) pathway which involves both activated factor IX and factor VIII . Both pathways lead to the activation of factor X ( the common pathway ) which combines with activated factor V in the presence of calcium and phospholipid to produce thrombin ( thromboplastin activity ).
43.
Factor XII does play an important role in clot formation during " in vitro " measurements of the partial thromboplastin time, which causes these measurements to be markedly prolonged in patients with factor XII deficiency, usually well beyond even what is seen in hemophilia A, hemophilia B, or factor XI deficiency.
44.
Immune regulating proteins found in prostasomes include : amino-peptidase N ( CD13 ); dipeptidyl-peptidase IV ( CD26 ); enkephalinase ( neutral endopeptidase, CD10 ); angiotensin converting enzyme ( ACE, CD143 ); tissue factor TF ( CD142, thromboplastin ); decay accelerating factor ( CD55 ); protectin ( CD59, inhibitor of MAC ) and complement regulatory membrane cofactor protein ( CD46 ).
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