It works as a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor.
42.
Lack of IL-10 has been shown to cause COX activation and resultant Thromboxane receptor activation to cause vascular endothelial and cardiac dysfunctions in mice.
43.
Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme ( the source of thromboxane A2 in platelets ).
44.
Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme ( the source of thromboxane A2 in platelets ).
45.
Guarana extract reduced aggregation of rabbit platelets by up to 37 percent below control values and decreased platelet thromboxane formation from arachidonic acid by 78 percent below control values.
46.
The cyclooxygenase pathway produces thromboxane, prostacyclin and prostaglandin D, E and F . Alternatively, the lipoxygenase enzyme pathway is active in leukocytes and in macrophages and synthesizes leukotrienes.
47.
This product is further metabolized by Thromboxane synthase to "'Thromboxane A2 "', "'12-Hydroxyheptadecatrienoic acid "', and malonyldialdehyde.
48.
This product is further metabolized by Thromboxane synthase to "'Thromboxane A2 "', "'12-Hydroxyheptadecatrienoic acid "', and malonyldialdehyde.
49.
It is a prominent product in Thromboxane A2 synthesis wherein cyclooxygenase 1 or cycloxygenase 2 metabolizes arachidonic acid to prostaglandin H2 by platelets and a wide array of other cell types and tissues.
50.
This non-enzymatic pathway may explain findings that cells can make 12-HHT in excess of TXA2 and also in the absence of active cycloxygenase and / or thromboxane synthase enzymes.
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