41. That went over as nicely suggestive but clean, topically pointed and disarmingly self-directed. 42. Aspirin is an anti-inflammatory and topically it reduces irritation from shaving and bee stings. 43. It is also used topically , in low doses for the treatment of chronic anal fissures. 44. When applied topically , it is made into a cream form using either vaseline or Phlojel. 45. It has been used topically and orally to treat hyperhidrosis, in particular, gustatory hyperhidrosis. 46. Eucalyptus oil also has anti-inflammatory and analgesic qualities as a topically applied liniment ingredient. 47. Also, potassium nitrate can be applied topically in an aqueous solution or an adhesive gel. 48. Topically these are high level discussions.49. Cocaine, the first local anesthetic was used topically in ophthalmology in 1884 by Carl Koller. 50. It has also been successfully used topically in a clinical trial as a treatment for diabetic neuropathy.