41. But vancomycin , the last line of defense against infections, is losing its punch. 42. For most of those infections, only one approved antibiotic, vancomycin , remains effective. 43. The dilemma over how and when to use vancomycin isn't confined to Britain. 44. In practice, MRSAs are resistant to many antibiotics and some to all but vancomycin . 45. Elizabeth and dozens of others with vancomycin -resistant infections have been helped by Synercid. 46. Now it is developing resistance to the last line of defense, the antibiotic vancomycin . 47. Candidates include clindamycin, Rifampin and vancomycin . 48. The caustic nature of vancomycin makes IV therapy using peripheral lines a risk for thrombophlebitis. 49. As resistance to other antibiotics has increased, doctors have turned to vancomycin with growing regularity. 50. Tenover said overuse and misuse of antibiotics is increasing the likelihood of vancomycin -resistant staph.