Fluoride was known to enhance the measurement of bone mineral density at the lumbar spine, but it was not effective for vertebral fractures and provoked more non vertebral fractures.
42.
Vertebral fractures, while having a smaller impact on mortality, can lead to a severe chronic pain of neurogenic origin, which can be hard to control, as well as deformity.
43.
Fluoride was known to enhance the measurement of bone mineral density at the lumbar spine, but it was not effective for vertebral fractures and provoked more non vertebral fractures.
44.
In tests by Lilly, Forteo reduced the risk of new vertebral fractures in older women with osteoporosis by about 65 percent, compared with 47 percent by the current best-selling osteoporosis drug.
45.
Lilly announced in August 2009 that preliminary results from a five-year clinical study showed that arzoxifene met its primary endpoints of reduction in vertebral fractures and breast cancer in postmenopausal women.
46.
In the 3 years results, reported in 2004, strontium ranelate showed significant reduction in vertebral fractures with 41 % and hip fractures with 36 % compared with patients treated with placebo.
47.
The bisphosphonate alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39 %; zoledronate reduces the risk of hip fractures by 38 % and of vertebral fractures by 62 %.
48.
The drug, known chemically as alendronate, reduced the risk of vertebral fractures by 48 percent and the risk of fractures elsewhere in the body by 21 percent when compared with a placebo.
49.
The RUTH Trial concluded that " benefits of raloxifene in reducing the risks of invasive breast cancer and vertebral fracture should be weighed against the increased risks of venous thromboembolism and fatal stroke ".
50.
Each year, this disease leads to 1 . 5 million broken bones, including more than 700, 000 vertebral fractures, 300, 000 hip fractures, 200, 000 wrist fractures and 300, 000 fractures of other bones.
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