1. Where anatoxin had the highest activity efficacy and tubocurare the lowest. 2. *I enjoyed watching the external video about anatoxin -a. 3. Anatoxin -a binding to these nAchRs cause the same effects in neurons.4. Studies have shown that some microorganisms are capable of degrading anatoxin -a. 5. In the same year JP Devlin and colleagues discovered the bicyclic secondary amine structure of anatoxin -a. 6. Many cases of wildlife and livestock deaths due to anatoxin -a have been reported since its discovery. 7. In mice, anatoxin -a also seriously impacted blood pressure and heart rate, and caused severe acidosis. 8. Acetylcholine on the other hand induced a much longer opening time of the receptor though anatoxin is more potent. 9. The results suggest that anatoxin derivatives would be helpful in understanding structure-activity relationships ( SAR ) for muscle nAChRs. 10. However, anatoxin -a binding is irreversible, and the anatoxin-a nAchR complex cannot be broken down by acetylcholinesterase.
