Furthermore, germ line duplication of brachyury confers major susceptibility to chordoma.
2.
Brachyury is an essential transcription factor required for mesoderm formation.
3.
Without MACF1, insufficient brachyury is transcribed, and hence, the mesoderm does not form.
4.
"Brachyury " has also been shown to help establish the cervical vertebral blueprint during fetal development.
5.
"Brachyury " is an important factor in promoting the epithelial-mesenchymal transition ( EMT ).
6.
As noted above germline duplication of brachyury has been identified as a major susceptibility mechanism in several chordoma families.
7.
In mice, the Brachyury gene is expressed in early mesoderm cells and its expression then becomes restricted to the notochord.
8.
The Brachyury protein binds as a dimer to a 20-nucleotide partially palindromic sequence recognized by its T-domain.
9.
These genes are grouped together on the basis of the homology existing between their products and the mouse Brachyury ( or T ) protein.
10.
Brachyury, MEK, and Aurora kinase A are molecular drivers of these programs, and inhibitors are currently in clinical trials to determine therapeutic applications.
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