1. The substitution pattern arises from the electron-withdrawing effect of the carboxyl group . 2. A carboxyfluorescein molecule is a fluorescein molecule with a carboxyl group added. 3. The carboxyl group is ionized at physiological pH, making the conjugated compound water-soluble. 4. Amine-modified oligonucleotide probes attached to carboxyl groups on quantum dots show sequence-specific hybridization. 5. The-COOH carboxyl group , being acidic, facilitates the action of histamine reaction. 6. The next reaction is catalyzed by the enzyme ?-carboxyl group of L-glutamate 5-phosphate. 7. It is active on peptide linkages involving the carboxyl group of lysine or arginine. 8. EEDQ is also a highly specific reagent for carboxyl groups . 9. In nature, around 80 percent of carboxyl groups of galacturonic acid are esterified with methanol. 10. This carboxyl group is also referred to as the beta subunit in the isocitrate molecule.