1. Neostigmine binds to the anionic and esteric site of cholinesterase . 2. This makes ester hydrolysis degradation by plasma cholinesterase more favourable. 3. The irreversible phosphorylation of the cholinesterase occurs in two steps. 4. Differentiated cells also have choline acetyltransferase and acetyl cholinesterase activities. 5. Many toxins and venoms produced by plants and animals also contain cholinesterase inhibitors. 6. Like most other organophosphates, its mode of action is via cholinesterase inhibition. 7. The cholinesterase serum test is usually done to measure exposure to organophosphate insecticides. 8. In the first step the cholinesterase gets reversibly phosphorylated. 9. But after this step the cholinesterase is irreversibly inhibited. 10. Solandine is responsible for neuromuscular syndromes via cholinesterase inhibition.
