1. The first simple enzyme mimics were based on crown ether and cryptand. 2. In the research lab, crown ethers are used for this purpose. 3. Lariat crown ethers have sidearms that can augment complexation of cation. 4. Crown ethers , like 15-crown-5, may be used as a phase-transfer catalyst.5. A chiral substituted crown ether catalyst developed by Jean-Marie Lehn for ester cleavage. 6. Like crown ethers , cyclen compounds are capable of selectively binding cations. 7. Since the salt is poorly soluble in nonpolar solvents, crown ethers are typically used. 8. A notable example of catalysts that employ this mechanism is Jean-Marie Lehn's crown ether . 9. Excess acid locks the crown ether by protonation and again the complex is dethreaded. 10. The bis-macrocycle ( red ) contains two phenanthroline units in a crown ether chain.
