1. There is little statistical evidence for contributions from overdominance and epistasis . 2. In synergystic epistasis , each additional mutation has increasing negative impact on fitness. 3. Durham invoked the concept of epistasis to explain the relationship between different factors. 4. :Maybe take a look at epistasis . 5. In antagonistic epistasis , the effect of each mutation declines with increasing numbers of mutation. 6. This interaction between genes is called epistasis , with the second gene epistatic to the first. 7. Bateson also coined the term " epistasis " to describe the genetic interaction of two independent traits. 8. This relationship between number of mutations and fitness is known as " synergistic epistasis ". 9. This systematic approach to studying epistasis on a genome wide scale has significant implications for functional genomics. 10. This has been integrated with these present covariances in an effort to provide estimators for the epistasis variances.