1. Androstenedione can be converted to testosterone, estrone , and estradiol. 2. Estrone and estradiol are also produced in the placenta during pregnancy.3. Estrone is a major estrogen that is normally found in women.4. Estrone sulfate is usually the major form of estrogen in women.5. It has estrogenic activity similarly to estrone and 4-hydroxyestrone. 6. Estrone was discovered and isolated by German chemist Adolf Butenandt.7. The transformation of estrone sulfate to estrone is catalyzed by estrone sulfatase. 8. The transformation of estrone sulfate to estrone is catalyzed by estrone sulfatase. 9. The transformation of estrone sulfate to estrone is catalyzed by estrone sulfatase. 10. As such, estrone is the main estrogen elevated in the condition.
