To prevent lethal gene dosage problems, one of these chromosomes is inactivated following fertilization.
2.
For some genes the phenotypic consequences of a decrease in gene dosage are noticeable but not catastrophic.
3.
HAND1 works jointly with HAND2 in cardiac development of embryos based on a crucial HAND gene dosage system.
4.
These slight gene dosage differences are responsible for variation in gene expression depending on the position on the chromosome.
5.
Hyperactivation is a term also used to express an X chromosome gene dosage compensation mechanism and is seen in Drosophila.
6.
Gene dosage effects after duplication can also be harmful to a cell and the duplication might therefore be selected against.
7.
Unlike single gene disorders, diseases caused by aneuploidy are the result of improper gene dosage, not nonfunctional gene product.
8.
The AMY1 gene is an excellent example of how gene dosage affects the survival of an organism in a given environment.
9.
Theoretically, X-inactivation should eliminate the differences in gene dosage between affected individuals and individuals with a normal chromosome complement.
10.
The alteration in the gene dosage, which is caused by the loss of a functional allele, is also called allelic insufficiency.
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