1. Thus, the haptoglobin will stay normal if the hemolysis is not severe. 2. In addition, the haptoglobin gene is expressed in murine and human adipose tissue. 3. This causes a decline in haptoglobin levels. 4. Therefore, haptoglobin is not a reliable way to differentiate between intravascular and extravascular hemolysis. 5. This appears to be because haptoglobin related protein and apolipoprotein L-1 are unique to primates. 6. The haem is then removed along with the bound haptoglobin from the blood by the reticuloendothelial system. 7. Levy and his colleagues found that two forms of haptoglobin were too large to do a good job. 8. In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. 9. It is theorized that, because of this, haptoglobin has evolved into an acute-phase protein. 10. Typical examples of glycoproteins consisting of glycoforms are the blood proteins as orosomucoid, antitrypsin, and haptoglobin .
